Benefits

• Structured progression into Medical Director or senior site leadership
• Portfolio exposure across multiple sponsor-led, commercially significant trials
• True clinical authority to influence study strategy and execution
• Mentor and develop junior doctors and future PIs

 
About the company
This is a rapidly expanding Australian CRO with a strong and growing national presence.
They specialise in high-quality, efficient clinical trials across healthy volunteers and complex therapeutic areas, partnering closely with sponsors and CROs.
With a modern Sydney site, the organisation is experiencing sustained growth, with strong sponsor demand and commercial momentum.
They specialise in large-scale trials across rheumatology, dermatology, diabetes, neurology, vaccines, and emerging indications, with plans to continue broadening their portfolio.
The structure is deliberately flat, with senior leaders working alongside site teams, creating a collaborative, fast-moving environment where decisions are made close to the work.
 
 
About the opportunity
This Principal Investigator role is a pivotal appointment supporting both immediate trial delivery and long-term site growth.
You will lead multiple active clinical trials while helping shape how studies are run, optimised, and scaled across the Sydney site.
Working closely with the Site Medical Director, CMO, Consultant PIs, and Operations Manager, you will have genuine influence over trial design decisions, recruitment strategies, and sponsor engagement.
The role offers exposure to a broad and diverse trial portfolio rather than being siloed into a single indication.
You will play a key role in mentoring Sub-Investigators and junior doctors, contributing to a clear internal pipeline from Sub-I to PI and beyond.
There is strong visibility with sponsors, giving you the opportunity to build trusted relationships and contribute medical insight that directly impacts study success and business growth.
This position suits a PI who values autonomy, commercial awareness, and the chance to grow alongside an organisation that is scaling quickly and investing in its people.

 
Duties

• Act as Principal Investigator on active clinical trials
• Provide medical oversight and participant safety leadership
• Lead and mentor Sub-Investigators and junior doctors
• Collaborate with sponsors, CROs, and internal teams
• Support recruitment, retention, and trial optimisation
• Ensure protocol, GCP, and regulatory compliance
• Contribute medical insight to feasibility and study setup

 

Skills and Experience

• Medical degree
• AHPRA unrestricted registration
• Clinical trial investigator experience
• Strong stakeholder communication

 

Culture
Collaborative, high-growth, no-hierarchy environment where ideas are valued, people are supported, and clinicians are trusted to think beyond the rulebook.
 

How to Apply 
Click apply or contact Eve Cooke, Senior Recruitment Consultant on 02 8877 8722 for a confidential discussion. 
 
 

About Healthcare Professionals Group
 
Healthcare Professionals Group recruits all positions: executive, permanent, contracting/temp, at all levels, across all areas of healthcare - Pharmaceuticals, Biotechnology, Medical Technology and Clinical Care.
 

• Medical Affairs & Life Sciences Recruitment - Clinical Research, Market Access, Medical Affairs, Pharmacovigilance, Quality, Data Management, Regulatory Affairs, Scientific;
• Commercial Recruitment - Marketing, Sales, Analytics, Government and External Affairs;
• Business Operations & Infrastructure Recruitment - Administration, Customer Service, Engineering, Finance, Human Resources, IT, L&D, Legal, Manufacturing, Operations, Supply Chain, Warehouse;
• Clinical Care Recruitment - Allied Health, Aged Care, General Practice, Medical Imaging, Medical Management, Medical Specialties, Nursing.

 
For more job opportunities, visit www.hpgconnect.com.